The Cumberland Marsh Region (CMR), located on the coast of the Bay of Fundy, is a major feeding ground for waterfowl and contains significant coastal wetland systems. In this study, concentrations of lead (Pb) and arsenic (As) were assessed in the bottom sediments of various open water wetlands across the CMR, and gastropods were sampled from the same wetlands to assess bioaccumulation of these nonessential trace elements and the potential for transfer to higher trophic level species. It was predicted that gastropods would have higher concentrations of Pb and As from wetlands with higher concentrations of these elements in sediments. Although wetland sediments and gastropods had elevated Pb and As concentrations, in some cases above the Canadian Sediment Quality Guidelines for the protection of aquatic life, there were no significant correlations between sediment and gastropod trace element concentrations. Gastropod to sediment ratios of Pb and As concentrations were highest in the brackish wetlands, but overall, levels were not of toxicological concern. Wetland chemistries and gastropod physiologies are hypothesized to be driving factors in determining the level to which Pb and As will bioaccumulate and merit careful consideration when developing wetland management strategies.