everal studies and meta-analyses 1,2 have indicated that the risk of schizophrenia and related psychoses is increased for people who use cannabis. The association appears to be particularly driven by heavy and frequent cannabis use. 2,3 This has led to a persisting hypothesis that cannabis may be a component cause of schizophrenia, at least in some people. This hypothesis is strengthened by several factors, such as strong attempts to control for reverse causation (eg, people self-medicating prodromal symptoms of schizophrenia). Similarly, cannabis-induced psychosis has been found to be associated with later onset of schizophrenia. [4][5][6] Furthermore, experimental evidence strongly suggests that cannabis, even in relatively low doses, causes psychoticlike symptoms in healthy individuals. [7][8][9]

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