No abstract

Since at least 1935, vision researchers have used art stimuli to test human response to complex scenes. This is sensible given the "inherent interestingness" of art and its relation to the natural visual world. The use of art stimuli has remained popular, especially in eye tracking studies. Moreover, stimuli in common use by vision scientists are inspired by the work of famous artists (e.g., Mondrians). Artworks are also popular in vision science as illustrations of a host of visual phenomena, such as depth cues and surface properties. However, until recently, there has been scant consideration of the spatial, luminance, and color statistics of artwork, and even less study of ways that regularities in such statistics could affect visual processing. Furthermore, the relationship between regularities in art images and those in natural scenes has received little or no attention. In the past few years, there has been a concerted effort to study statistical regularities in art as they relate to neural coding and visual perception, and art stimuli have begun to be studied in rigorous ways, as natural scenes have been. In this minireview, we summarize quantitative studies of links between regular statistics in artwork and processing in the visual stream. The results of these studies suggest that art is especially germane to understanding human visual coding and perception, and it therefore warrants wider study.

No abstract

Cadherins are a family of cell surface molecules mediating calcium-dependent cell-cell adhesion in a variety of tissues. More than a dozen cadherins are expressed in the vertebrate brain. To obtain insight into the biological significance of this diversity in cadherin expression, we mapped the expression of N- and R-cadherin in the brain of the developing chicken embryo (days 2-19 of incubation) by immunohistochemical and in situ hybridization techniques. Whereas the expression of N- and R-cadherin is relatively uniform or weak in early (about 2-5 days of incubation) and late development (15 days of incubation to hatching stage), these two molecules are differentially expressed in specific nuclei and fiber tracts between days 6-11 of incubation. For example, in the mes- and diencephalon, one of the tectofugal pathways and its target nuclei, here called the tecto-pretecto-rotundal system, express N-cadherin. R-cadherin is expressed by a different tectofugal system, the tectoisthmic pathway. The other tectofugal systems express neither N- nor R-cadherin. In addition, a small number of other mes- and diencephalic nuclei express N- or R-cadherin. On the basis of these results and experimental evidence from other studies, we speculate that the two cadherins are involved in the formation and segregation of particular functional systems within the vertebrate central nervous system (CNS) by regulating the formation of nuclei, and the pathfinding and/or the selective fasciculation of neurites. Apart from neuronal elements, a variety of vascular and ependymal structures also express N-cadherin or R-cadherin, e.g., the parenchymal blood vessels, the choroid plexus, the floor and roof plates, and the ventricular lining. These findings suggest that the two cadherins play a variety of roles during the development of neuronal and nonneuronal epithelial structures throughout CNS development.