State-of-the-art lung support systems are limited to short time application because of a lack of long term hemocompatibility and protein absorption on the membrane surfaces. In a highly interdisciplinary project at RWTH Aachen University a biohybrid lung assist system with endothelialised gas exchange flat membranes is developed to improve long term compatibility of oxygenators. To increase the gas exchange performance of flat membranes hollows are imprinted in the membrane surfaces. This approach is based on the research of B. J. Bell-house et al. [1], who discovered this effect, now known as Bellhouse-effect, around 1960. In this paper a processes to manufacture membrane assemblies for oxygenation with imprinted hollows on the flat membrane surfaces is reviewed.

The objective of this paper is to determine wounds, wound healing and the effect of nutrition on wound healing. In recent times, the developments in cellular and molecular biology have greatly expanded and enhanced the current understanding of the biological processes involved in wound healing and tissue regeneration. A remarkable progress has been achieved and an ever-growing number of wound care products have been designed and developed to incorporate the latest understanding of cellular and molecular level phenomena involved in the dynamic and complex process of wound healing, including blood coagulation, inflammation, fibroplasias, collagen deposition and wound contraction. The primary goals of innovations are aimed at alleviating patient suffering; shortening wound healing time periods, and resolving chronic wound healing clinical problems. The investigation and innovation of novel wound dressing materials and methods are an important part of the fast growing biomaterials industry worldwide.