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The potential for inducing hypotension during fentanyl anaesthesia by administering either diltiazem (n = 7) or sodium nitroprusside (n = 7)

Eighteen normal volunteers with no sleep difficulties were given psychological tests and asked to fill out a self-evaluation questionnaire 11 h after administration of a hypnotic drug, nitrazepam 5 rng or temazepam 20 mg (in the form of soft gelatin capsules), which was compared to a placebo. Subjects received all three treatments at 1-week intervals, with the administration sequence determined by drawing lots. The tests used were the images test, the digitlsymbol substitution test (DSST), choice reaction time and critical fusion frequency. The two benzodiazepines proved to be efficient hypnotics, improving sleep induction and quality, but nitrazepam caused residual effects, as evidenced by difficult awakening and modified behaviour in the morning, as well as disturbed performance during DSST.

No abstract