authors' goal was to screen for genetic linkage with mghly infonnative deoxyribonucleic acid (DNA)Urosatellite markers on a series of moderately sized HDrth American bipolar disorder (BP) pedigrees. These IP pedigrees were genotyped with 57 short tandem rrptIlt polymorphic systems (microsatellites) that were tcymIltiCll lly amplified from genomic DNA. We did not ,., significant evidence for genetic linkage. We found II\' WORDS: Mapping; Bipolar illness; Microsatellites; Gmtti c linkage simulations; GNASl; Human X-linked GABA-A receptor a3-subunit gene A body of epidemiologic studies implies that there is l&metic component that confers susceptibility to bipo
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