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Background: There is a correlation between the sites of atheroma development and stress points in the arterial system. Generally, pulse pressure results in stresses acting on the vascular vessel, including longitudinal stress, radial or normal stress, tangential stress or hoop stress and shear stress. This paper explores the relationship between arterial wall shear stress and pulsatile blood pressure with the aim of furthering the understanding of atherogenesis and plaque progression. Methods:We computed the magnitude of the shear stresses within the carotid bifurcation geometry of a patient and calculated the increase in shear stress levels that would occur when the blood pressure and pulse pressures rise during exertion. We also determined in which layer of the artery wall the maximum shear stress is located, and computed the shear stress at different levels within the media. We used the theory of laminate analysis, (Classical Laminate Plate Theory), to analyse the stress distribution on the carotid artery wall. Computational Fluid Dynamics (CFD) analysis was used on anatomy based on a CT angiogram of the carotid bifurcation of a patient with a 90% stenosis on the right side and 10% on the left. The pulsatile non-Newtonian blood flow with a resting blood pressure of 120/80 mmHg and an exertion pressure of 200/100 mmHg was simulated and the resultant forces were transferred to an ANSYS Composite PrepPost (ACP) model for wall shear stress analysis. A multilayer elastic, anisotropic, and inhomogeneous arterial wall (intima, internal elastic lamina, media, external elastic lamina, and adventitial layers) was modelled and the shear stress magnitudes and change over time between the layers was calculated.Results: Shear stress in the individual composite layers is far greater than that acting on the endothelium (less than 5 Pa). At rest, the maximum variation of shear stress in the arterial wall occurs in the intima (138 Pa) and adventitia (135 Pa). The medial layer has the lowest variation of shear stress. Under severe exertion, the maximum shear stress magnitude in the intimal layer and the adjacent medial layer is near the ultimate stress level. The maximum/minimum shear stress ratios during the cardiac cycle vary most widely in the innermost part of the media, adjacent to the intima, with a four-fold ratio increase. This compares with a less than two-fold increase in all the other layers including the intima and adventitia, making the inner media the most vulnerable layer to mechanical injury.Conclusions: This study showed that the magnitude of exertion-induced shear stress approaches the ultimate stress limit in the intima and the immediate adjacent medial layer. The variation in stress is maximal in the inner layer of the media. These findings correlate the site of atheroma development with the most vulnerable site for injury in the media and emphasise the impact of pulse pressure. Further biological studies are required to ascertain whether this leads to injury that initiates atheroma that then precipitates an ...

Development of shale gas reservoirs is the fastest growing area on a large scale globally due to their potential reserves. CO2 has a great affinity to be adsorbed on shale organic surface over CH4. Therefore, CO2 injection into shale reservoirs initiates a potential for enhanced gas recovery and CO2 geological sequestration. The efficiency of CO2 enhanced gas recovery (CO2-EGR) is mainly dominated by several shale properties and engineering design parameters. However, due to the heterogeneity of shale reservoirs and the complexity of modeling the CO2–CH4 displacement process, there are still uncertainties in determining the main factors that control CO2 sequestration and enhanced CH4 recovery in shale reservoirs. Therefore, in view of the previous sensitivity analysis studies, no quantitative framework, accurate CO2-EGR modeling, or design process has been identified. Thus, this work aimed to provide a practical screening tool to manage and predict the efficiency of enhanced gas recovery and CO2 sequestration in shale reservoirs. To meet our objectives, we performed correlation analysis to identify the strength of the relationship between the examined shale properties and engineering design parameters and the efficiency of CO2-EGR. Data for this study was gathered across publications on a wide subset of numerical modeling studies and experimental investigations. The sensitivity of data was further improved by a hybrid approach adopted for handling the missing values to avoid bias in our data set. Our results indicate that CO2 flooding might be the best applicable option for CO2 injection in shale reservoirs, whereas the huff-and-puff scenario does not seem to be a viable option. The efficiency of CO2-EGR increases as the pressure difference between injection pressure and reservoir pressure increases. The results show that shallow shale reservoirs with high fracture permeability, total organic content, and CO2–CH4 preferential adsorption capacity are favorable targets for CO2-EGR. Moreover, our results indicate that a successful hydraulic-fracture network with effective values of fracture permeability and conductivity is essential for a higher CO2-EGR efficiency. Well spacing and fracture half-length are crucial engineering features in CO2-EGR process design that must be carefully optimized due to their negative effect on CH4 production and positive effect on CO2 storage. Our statistical analysis lays a foundation for efficient CO2-EGR design and implementation and presents an important contribution to the field of reaching the target of net-zero CO2 emissions for energy transitions.

One of the major challenges faced by oil extraction industry is the unstable behavior of asphaltene formation, yet not fully understood. The prediction of asphaltene formation depends on the small changes in chemical characteristics and composition of the crude oil. Consequently, the study of molecular structure and molecular properties such as density is of a great practical interest. Other properties become very complex to assess when the asphaltene fraction contains 10 5 different molecules. Average molecular parameters are used to obtain information about asphaltenes. The density of the asphaltenes can easily be calculated and, thus, can be used to evaluate predictive capacities of the average structure. This present work of molecular dynamic simulations was carried out to evaluate the asphaltene densities of an Australian oil field. Simulations of molecular dynamics are used to assess the average structure densities representing different asphaltenes in a specific oil field. These simulations assist in predicting the formation of asphaltene structural model. Comparatively, the experimental densities are higher than the calculated ones. However, the calculated values demonstrate the appropriate trend. The chemical structure shows essential accuracy, as evidenced by average structures, which can be used to estimate the densities qualitatively. Hence, systematic study was carried out on the basis of the effects of various structures on the calculated densities of asphaltene. The main characteristics of the molecules which yielded highest densities are those found with low hydrogen-carbon ratio and big condensed aromatic rings. Moreover, better and improved density values were produced by a recently developed group contribution method than simulations of molecular dynamics, which is still being lower than that of experimental values.