BACKGROUND Gastric adenocarcinoma is one of the most common cancers in the world and 2nd most common cause of cancer deaths. It develops due to genetic and environmental factors. Histologically, Lauren's classified Gastric adenocarcinoma is classified into intestinal and diffuse types. Intestinal type can be of well differentiated, moderately differentiated or poorly differentiated. E-cadherin is a protein that helps in cell to cell adhesion. This study is conducted to find out relation between E-cadherin expression and tumour infiltration and lymph node status. MATERIALS AND METHODS A descriptive study was conducted to assess E-cadherin expression in gastric adenocarcinoma specimens received in the Department of Pathology, Govt. Medical College, Kottayam during a period of 15 months (March 2016-June 2017). RESULTS Among 46 cases studied, 40 (80%) cases showed aberrant/ loss of E-cadherin expression. Among these 16 (72%) cases were well differentiated type, 5 (100%) cases were moderately differentiated, 2 (100%) cases were poorly differentiated and 17 (100%) cases were diffuse type. Aberrant/ loss of expression is seen in 29 (87%) cases of lymph node positivity. Aberrant/ loss of expression is seen in 37 (88%) cases of T3/T4 stage. CONCLUSION In the study aberrant E-cadherin expression was seen in 74% cases, loss of expression in 13% cases and normal expression in 13% cases. A negative correlation was seen between E-cadherin expression and lymph node status. Level of tumour invasion also had a negative correlation with E-cadherin expression.