BackgroundGranular cell ameloblastoma is a rare histological subtype of ameloblastoma accounting for less than 5% of the total. The characteristic microscopic features of granular cells are attributed to the increased presence of lysosomes in the cytoplasm of the tumour cells.MethodsA case of bone expansion in the mandible of 65 year old patient was examined on the basis of the clinical examination, radiographic imaging and microscopic features. A complete surgical removal was performed.ResultsThe radiographic imaging characteristics were consistent with a locally aggressive jaw lesion. Histological examination of the tumour revealed typical features of granular cell ameloblastoma. The specimen margins were free of tumour and the postoperative course was uneventful. No evidence of recurrence was noticed during a 1.5 years follow-up period.ConclusionsThe rarity of the granular cell ameloblastoma subtype and the possibility of confusion with other odontogenic and non-odontogenic lesions with a granular cell component require an understanding of the salient features of this locally aggressive neoplasm. A literature review is provided focusing on emerging molecular parameters in the pathogenesis of these tumours and the differential diagnosis of oral lesions featuring granular cells.

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SažetakNazolabijalna cista je neodontogenog podrijetla i nastaje od ostataka epitela nazolakrimalnog kanala. Klinički se očituje kao unilateralna, rijetko bilateralna, meka fluktuirajuća oteklina u nazolabijalnom području. Može uzrokovati obliteraciju nazolabijalnog nabora te odizanje nosnih krila. Iako je asimptomatska, ova cista može, ako se inficira, uzrokovati bol. Najčešće zahvaća že-ne u četvrtom i petom desetljeću. Osim na temelju kliničkih obilježja, dijagnosticira se CT-i MRsnimkama. Konačna dijagnoza potvrđuje se histopatološkom analizom. Terapija izbora je kirurška enukleacija oralnim pristupom sublabijalno. U ovom članku opisan je tretman nazolabijalne ciste kod 42-godišnje žene. Uz prikaz slučaja priložen je i kratak pregled literature.Ključne riječi neodontogene ciste; nosno-suzni kanal; nosno-usna brazda Zavod za oralnu medicinu i patologiju Stomatološkog fakulteta Aristotelova sveučilišta, Solun, Grčka