The Cancer Genomics Hub (CGHub) is the online repository of the sequencing programs of the National Cancer Institute (NCI), including The Cancer Genomics Atlas (TCGA), the Cancer Cell Line Encyclopedia (CCLE) and the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) projects, with data from 25 different types of cancer. The CGHub currently contains >1.4 PB of data, has grown at an average rate of 50 TB a month and serves >100 TB per week. The architecture of CGHub is designed to support bulk searching and downloading through a Web-accessible application programming interface, enforce patient genome confidentiality in data storage and transmission and optimize for efficiency in access and transfer. In this article, we describe the design of these three components, present performance results for our transfer protocol, GeneTorrent, and finally report on the growth of the system in terms of data stored and transferred, including estimated limits on the current architecture. Our experienced-based estimates suggest that centralizing storage and computational resources is more efficient than wide distribution across many satellite labs.Database URL: https://cghub.ucsc.edu

No abstract

The public reperting burden for this collection of information is estimated to average 1 hour per response. Inclu tonlyr quantities suitable for industrial applications, has been working to advance the application base ofgJ1lphene. We have recently demonstrated in laser protection applications, that graphene-based suspensions show non-Linear reductions in the transmission of high energy laser light. In this study, methods to improve the suspension dispersion and stability were developed. In addition, parameters that yield the unique NLO characteristics of graphene suspensions and the mechanisms leading to the NLO property in graphene suspensions were investigated.

No abstract

No abstract