Purpose. Cardiac complications are common in patients with spontaneous intracerebral hemorrhage (ICH). The present study is aimed at observing the incidence of cardiac complications after ICH, so as at improving the understanding of the relationship between cardiac complications and ICH. Methods. This is a retrospective study on analyzing electrocardiogram (ECG) and serum myocardial enzyme of 208 patients with ICH admitted to a tertiary hospital from 2018 to 2019. For each patient, demographics, medical history, clinical presentation, ECG, serum myocardial enzyme, and head CT on admission were reviewed. Mortality was noted. Results. Among the 208 patients, 145 (69.71%) had one or more ECG abnormalities. The top three abnormalities were corrected QT interval (QTc) prolongation 52 (25%), ST depression 48 (23.08%), and T wave inversion 38 (18.27%). One hundred and thirty-nine patients (66.83%) had increased serum levels of at least one kind of myocardial enzyme, which were high-sensitive cardiac troponin T (hs-cTnT) 79 (37.98%), lactic dehydrogenase (LDH) 80 (38.46%), creatine kinase (CK) 57 (27.40%), and creatine kinase-myocardial subfraction (CKMB) 57 (27.40%). The logistic regression analysis showed the following: secondary intraventricular hemorrhage (SIVH) (odds ratio (OR) 5.32; 95% confidence interval (CI) 2.55–11.08; p < 0.001 ) and hematoma volume > 30  ml (OR 3.81; 95% CI 1.86–7.81; p < 0.001 ) were independent predictive factors of QTc prolongation; thalamus location (OR 5.79; 95% CI 1.94–17.28; p < 0.05 ), hematoma volume > 30  ml (OR 24.187; 95% CI 3.14-186.33; p < 0.05 ), insular involvement (OR 19.08; 95% CI 5.77-63.07; p < 0.001 ), and SIVH (OR 2.62; 95% CI 1.69-5.86; p < 0.05 ) were independent predictive factors of ST depression; insular involvement (OR 2.90; 95% CI 1.12–7.50; p < 0.05 ) and hematoma volume > 30  ml (OR 1.98; 95% CI 1.06–3.70; p < 0.05 ) were independent predictive factors of increase of CK; Glasgow Coma Scale (GCS) (OR 0.86; 95% CI 0.78–0.98; p < 0.05 ) and insular involvement (OR 5.56; 95% CI 1.98–15.62; p < 0.05 ) were independent predictive factors of increase of CKMB; SIVH (OR 2.05; 95% CI 1.07–3.92; p < 0.05 ) was independent predictive factor of increase of LDH; age (OR 1.03; 95% CI 1.01–1.06; p < 0.05 ), blood glucose on admission (OR 1.10; 95% CI 1.01–1.20; p < 0.05 ), and history of antiplatelet drug use (OR 3.50; 95% CI 1.01–12.12; p < 0.05 ) were independent predictive factors of hs-cTnT. All the injury indexes were not related to in-hospital mortality. Conclusion. The study suggests that insular involvement, hematoma volume > 30  ml, and SIVH are the strongest risk factors for ECG abnormalities and elevated myocardial enzymes after ICH followed which are the risk factors such as GCS, age, admission blood glucose, and ICH location in the thalamus.

ABSTRACT. The aim of this study was to investigate the N-terminal brain natriuretic peptide precursor (NT-proBNP) levels in the peripheral blood of patients with acute coronary syndrome (ACS) and to provide the basis for its application in the early diagnosis of ACS. A total of 440 patients admitted to the hospital for examination and treatment were enrolled, including 330 patients with ACS and 110 cases in the control group. Routine blood examination and determination of NT-proBNP in all subjects were conducted immediately at the time of admission to analyze the difference in plasma NT-proBNP between the two groups. The plasma NT-proBNP levels in ACS were significantly higher (P < 0.01) and were associated with the severity of coronary lesions. The present study indicated that the plasma NT-proBNP level in ACS patients is significantly increased and has a potential value in the early diagnosis of ACS.

The study aimed to detect the genetic polymorphism of apolipoprotein E (Apo E) in residents of Guizhou, China, explore its relationship with essential hypertension, and discuss the efficacy of nanotechnology in the treatment of hypertension. A total of 200 people in Guizhou, China were detected with Apo E polymorphisms and were divided into groups, The experimental group consists of people with essential hypertension and the control group of normal people. The SPSS 26.0 software was used to determine the correlation between Apo E gene polymorphisms and the essential hypertension risk. Logistic regression analysis was adopted to determine the risk factors of the Apo E gene for essential hypertension. Magnetic nanoparticles are used to help extract DNA, improve efficiency, and analyze the distribution of alleles in the population. The distribution frequencies of the six genotypes of E2/2, E2/3, E3/3, E3/4, E2/4, and E4/4 were 1.0%, 15.5%, 64.0%, 17.0%, 1.5%, and 1.0%, respectively, and the distribution frequencies of the three alleles of ε2, ε3, and ε4 were 9.5%, 80.3%, and 10.3%, respectively. There are more Apo E gene ε4 carriers in the experimental group than the control group, and the difference was statistically significant (P <0.05). The Apo E ε4 allele carriers had higher low-density lipoprotein and Apo B levels than the Apo E ε3 and Apo E ε2 gene carriers. Family history of hypertension and Apo E ε4 were both the main risk factors for essential hypertension. This study investigated the relationship between apolipoprotein E gene polymorphism and essential hypertension, and extracted DNA by magnetic nanoparticles to help analyze the distribution of alleles in hypertension population, which could provide theoretical basis for the diagnosis and treatment of essential hypertension in Guizhou Province, China.