The study compared the degree of social distance towards the mentally ill between the public, health workers and relatives of the mentally ill at Madonna University Teaching Hospital, Elele, Rivers State of Nigeria. It took place within 10 months. Two hundred and sixty nine consenting subjects were enlisted in the study. However only 254 completed it comprising 110 relatives of the mentally ill, 47 health workers and 97 non-relatives (public). The modified Bogardus Social Distance Scale (MBSDS) and a self designed questionnaire containing socio-demographic and psychiatric illness variables were administered to each subject. The difference in mean MBSDS scores of the public and relatives of the mentally ill is statistically significant, while the difference in mean MBSDS scores of the public and health workers is not statistically significant. The greatest proportion of respondents (37%) attributed the cause of mentally illness to demonic possession. Stigma towards the mentally ill is not only an important global health concern, but it is a burning human right issue.