Uma série de benzotiazóis 2-substituídos foi sintetizada pela condensação de 2-aminotiofenol com aldeídos (RCHO: R = Alquil, Aril, Heteroaril, 2-Arilformil) na presença de quantidade catalítica de brometo de cetiltrimetil amônio (CTAB) em água e sem adição de solventes orgânicos e oxidantes. Assim, usando esse protocolo, 2-alquilbenzotiazóis foram sintetizados em altos rendimentos e 2-arilformilbenzotiazóis foram obtidos pela condensação de 2-aminotiofenol com arilformil aldeídos pela primeira vez.A series of 2-substituted benzothiazoles have been synthesized by the condensation of 2-aminothiophenol with aldehydes (RCHO: R = Alkyl, Aryl, Heteroaryl, 2-Arylformyl) in the presence of a catalytic amount of cetyltrimethyl ammonium bromide (CTAB) "on water" by a onepot procedure without additional organic solvents and oxidants. Thereinto, 2-alkylbenzothiazoles were synthesized in high yields and 2-arylformylbenzothiazoles were obtained from the condensation of 2-aminothiophenol with arylformyl aldehydes for the first time using the present protocol.

A palladium-catalyzed coupling-type reaction of arylglyoxals with arylboronic acids was achieved by use of trimesitylphosphine as the ligand and K 2 CO 3 as base in toluene, providing symmetrical and unsymmetrical benzil derivatives with yields ranging from moderate to excellent. Of particular mention, the rigorous exclusion of air and moisture is not required in these transformations.

A simple, sensitive and accurate reversed-phase high-performance liquid chromatographic (HPLC) method for simultaneous determination of three naturally occurring estrogenic steroids including estrone (E1), 17β-estradiol (E2) and estriol (E3) in environmental water samples was developed. Analytes were extracted with ethyl acetate solvents and preconcentrated prior to HPLC analysis. Separations were accomplished in <20 min using a reversed-phase C(18) column (4.6×250 mm id, 5 μm) with a gradient elution of mobile phase containing 3.0 mM ammonium acetate/acetonitrile mixtures (flow rate, 1.0 mL/min). UV light absorption responses at 205 nm were linear over a wide concentration range from 100,000 μg/L to the detection limits of 0.96 μg/L E1, 0.64 μg/L E2 and 0.78 μg/L E3. Quantitation was carried out by the peak area method. The relative standard deviation for the analysis of three estrogens was <3.0%. This method was applied for the simultaneous determination of estrogens in environmental water samples collected in Zhejiang, China. The higher concentrations of both E2 and E3 were found in Tang River and West Lake waters, and E1 was detected in lake water only. All three estrogens were below the detection limits in rain waters.

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