A series of meso-substituted N-confused porphyrins (NCP) is synthesized using the modified Rothemund-Lindsey procedure. Lanthanide N-confused

An unprecedented series of (monophthalocyaninato)lantha-

5,10,15,20-tetrakis(4-amidinophenyl)porphyrin (Por 1), its Zn complex (Por 2) and its conjugate with a tetraphenylporphyrin to form a bisporphyrin (Por 3) were prepared. The monomeric Por 1 and Por 2 showed both intercalative and external binding with DNA whereas only external DNA binding was seen in the bisporphyrin, Por 3 by circular dichroism and UV-vis. The DNA photocleavage activities of these porphyrins followed the order: Por 1 ~ Por 2 > Por 3, which did not correlate with their measured 1O2 production rates. It suggests 4-amidinophenylporphyrins are promising new photodynamic therapeutic agents.

The synthesis and characterization of three nonperipherally substituted, covalently-linked phthalocyanine-porphyrin hybrid molecules is described. The optical and photophysical properties of these compounds are studied in detail. The intramolecular energy transfer process is investigated and quantified in terms of the quantum yield of the energy transfer and is found to be highly effective in these molecules.

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