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Purpose The purpose of this study was to examine the influence of repeated vibration stimulus on wrist and elbow flexor muscle of chronic stroke patient to hand dexterity, grip strength and activities of daily living. Methods The 23 subjects were participated in this study and randomly divided to two groups: vibration group, non-vibration group. Vibration group received vibration stimulus on wrist and elbow flexor muscle 5times a week for 2 weeks and to examine its effectiveness, and study conducted re-evaluation 2 weeks after intervention. 23 participants were measure using Fugl Meyer Assessment(FMA), Box and Block Test(BBT), JAMAR hand dynamometer, Modified Barthel Index (MBI). Results Vibration group and non-vibration group were significantly difference FMA total, BBT, JAMAR hand dynamometer(p<.05). Only vibration group was significantly difference between pre and post in FMA wrist(p<.05). Also, when comparing the changes value between the group pre and post BBT shower significantly difference(p<.05), and comparing the changes value between the group pre and 2 weeks after intervention JAMAR hand dynamometer showed significantly difference(p<.05). But, MBI was not significantly difference(p>.05) Conclusion Repeated vibration stimulus on wrist and elbow flexor muscle of chronic stroke patient was improved hand dexterity, grip strength and furthermore, grip strength showed effectiveness after intervention.