Dess–Martin periodinane (DMP) is a broadly applicable oxidant in chemical synthesis. In this work, an efficient and convenient synthesis of N-substituted isoquinolinone derivatives mediated by DMP was achieved through the oxidative coupling reaction of functionalized isoquinoline with readily available benzyl bromide, which is a metal-free, mild, and practical method for synthesizing isoquinoline-1,3-dione or isoquinoline-1,3,4-trione derivatives in excellent yields. The H2O18-labeling experiment was performed to gain insight into the possible mechanism for this reaction.

A method for the effective and rapid synthesis of perhydrofuro[2,3-b]-pyran from 1,2-cyclopropane sugar and indole is described. New scaffolds were rapidly constructed within 10 minutes in the presence of BF 3 • Et 2 O. Novel 2,2-disubstituted perhydrofuro[2,3-b]-pyran products containing various indoles were obtained in medium to excellent yields.