In this study, the Pauli blocking potential between two colliding nuclei in the density overlapping region is applied to describe the heavy nuclei fusion process. Inspired by the Pauli blocking effect in the
-decay of heavy nuclei, the Pauli blocking potential of single nucleon from the surrounding matter is obtained. In fusion reactions with strong density overlap, the Pauli blocking potential between the projectile and target can be constructed using a single folding model. By considering this potential, the double folding model with a new parameter set is employed to analyze the fusion processes of 95 systems. A wider Coulomb barrier and shallower potential pocket are formed in the inner part of the potential between the two colliding nuclei, compared to that calculated using the Akyüz-Winther potential. The fusion hindrance phenomena at deep sub-barrier energies are described well for fusion systems
O +
Pb and
Ni +
Ni.
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