Non-apoptotic ferroptosis is of clinical importance because it offers a solution to the inevitable biocarriers of traditional apoptotic therapeutic means. Inspired by industrial electro-Fenton technology featured with electrochemical iron cycling, we construct ferrous-supply-regeneration nanoengineering to intervene tumorous iron metabolism for enhanced ferroptosis. Fe 3+ ion and naturally derived tannic acid (TA) spontaneously form a network-like corona onto sorafenib (SRF) nanocores. The formed SRF@Fe III TA nanoparticles can respond to a lysosomal acid environment with corona dissociation, permitting SRF release to inhibit GPX4 enzyme for ferroptosis initiation. TA is arranged to chemically reduce the liberated and the ferroptosis-generated Fe 3+ to Fe 2+ , offering iron redox cycling to, thus, effectively produce lipid peroxide required in ferroptosis. Sustained Fe 2+ supply leads to long-term cytotoxicity, which is identified to be specific to H 2 O 2 -overloaded cancer cells but minimal in normal cells. SRF@Fe III TA-mediated cell death proves to follow the ferroptosis pathway and strongly inhibits tumor proliferation. Moreover, SRF@Fe III TA provides a powerful platform capable of versatile integration between apoptosis and non-apoptosis means. Typically, photosensitizer-adsorbed SRF@Fe III TA demonstrates rapid tumor imaging owing to the acid-responsive fluorescence recovery. Together with ferroptosis, imaging-guided photodynamic therapy induces complete tumor elimination. This study offers ideas about how to advance anticancer ferroptosis through rational material design.

Solar-driven water evaporation represents an environmentally benign method of water purification/desalination. However, the efficiency is limited by increased salt concentration and accumulation. Here, we propose an energy reutilizing strategy based on a bio-mimetic 3D structure. The spontaneously formed water film, with thickness inhomogeneity and temperature gradient, fully utilizes the input energy through Marangoni effect and results in localized salt crystallization. Solar-driven water evaporation rate of 2.63 kg m−2 h−1, with energy efficiency of >96% under one sun illumination and under high salinity (25 wt% NaCl), and water collecting rate of 1.72 kg m−2 h−1 are achieved in purifying natural seawater in a closed system. The crystalized salt freely stands on the 3D evaporator and can be easily removed. Additionally, energy efficiency and water evaporation are not influenced by salt accumulation thanks to an expanded water film inside the salt, indicating the potential for sustainable and practical applications.

Solar‐driven water evaporation has been considered a sustainable method to obtain clean water through desalination. However, its further application is limited by the complicated preparation strategy, poor salt rejection, and durability. Herein, inspired by superfast water transportation of the Nepenthes alata peristome surface and continuous bridge‐arch design in architecture, a biomimetic 3D bridge‐arch solar evaporator is proposed to induce Marangoni flow for long‐term salt rejection. The formed double‐layer 3D liquid film on the evaporator is composed of a confined water film for water supplementation and a free‐flowing water film with ultrafast directional Marangoni convection for salt rejection, which functions cooperatively to endow the 3D evaporator with all‐in‐one function including superior solar‐driven water evaporation (1.64 kg m‐2 h‐1, 91% efficiency for pure water), efficient solar desalination, and long‐term salt‐rejecting property (continuous 200 h in 10 wt% saline water) without any post‐cleaning treatment. The design principle of the 3D structures is provided for extending the application of Marangoni‐driven salt rejection and the investigation of structure‐design‐induced liquid film control in the solar desalination field. Furthermore, excellent mechanical and chemical stability is proved, where a self‐sustainable and solar‐powered desalination–cultivation platform is developed, indicating promising application for agricultural cultivation.