Selectively cuting off the nutrient supply and the metabolism pathways of cancer cells would be a promising approach to improve the efficiency of cancer treatment. Here, a cancer targeted cascade bioreactor (designated as mCGP) was constructed for synergistic starvation and photodynamic therapy (PDT) by embedding glucose oxidase (GOx) and catalase in the cancer cell membrane-camouflaged porphyrin metal-organic framework (MOF) of PCN-224 (PCN stands for porous coordination network). Due to biomimetic surface functionalization, the immune escape and homotypic targeting behaviors of mCGP would dramatically enhance its cancer targeting and retention abilities. Once internalized by cancer cells, mCGP was found to promote microenvironmental oxygenation by catalyzing the endogenous hydrogen peroxide (HO) to produce oxygen (O), which would subsequently accelerate the decomposition of intracellular glucose and enhance the production of cytotoxic singlet oxygen (O) under light irradiation. Consequently, mCGP displayed amplified synergistic therapeutic effects of long-term cancer starvation therapy and robust PDT, which would efficiently inhibit the cancer growth after a single administration. This cascade bioreactor would further facilitate the development of complementary modes for spatiotemporally controlled cancer treatment.

Non-apoptotic ferroptosis is of clinical importance because it offers a solution to the inevitable biocarriers of traditional apoptotic therapeutic means. Inspired by industrial electro-Fenton technology featured with electrochemical iron cycling, we construct ferrous-supply-regeneration nanoengineering to intervene tumorous iron metabolism for enhanced ferroptosis. Fe 3+ ion and naturally derived tannic acid (TA) spontaneously form a network-like corona onto sorafenib (SRF) nanocores. The formed SRF@Fe III TA nanoparticles can respond to a lysosomal acid environment with corona dissociation, permitting SRF release to inhibit GPX4 enzyme for ferroptosis initiation. TA is arranged to chemically reduce the liberated and the ferroptosis-generated Fe 3+ to Fe 2+ , offering iron redox cycling to, thus, effectively produce lipid peroxide required in ferroptosis. Sustained Fe 2+ supply leads to long-term cytotoxicity, which is identified to be specific to H 2 O 2 -overloaded cancer cells but minimal in normal cells. SRF@Fe III TA-mediated cell death proves to follow the ferroptosis pathway and strongly inhibits tumor proliferation. Moreover, SRF@Fe III TA provides a powerful platform capable of versatile integration between apoptosis and non-apoptosis means. Typically, photosensitizer-adsorbed SRF@Fe III TA demonstrates rapid tumor imaging owing to the acid-responsive fluorescence recovery. Together with ferroptosis, imaging-guided photodynamic therapy induces complete tumor elimination. This study offers ideas about how to advance anticancer ferroptosis through rational material design.

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This study reports a family of photothermal materials, metal ion/tannic acid assemblies (MITAs). MITAs from Fe, V, and Ru afford excellent photothermal efficiency (η ≈ 40%). Sharply differing from the currently existing photothermal agents, MITAs are highlighted by merits including green synthesis, facile incorporation of diagnostic metal ions, and particularly topology-independent adhesion. Owing to the adhesion nature of MITAs, various kinds of MITA-based nanoengineerings are readily available via the self-adhesion of MITAs onto diverse templates, enabling MITAs well suited as a photothermal platform for versatile combination with other therapy approaches and imaging techniques. As a proof of concept, polymeric/inorganic nanoparticle/nanovesicle-supported Fe-tannic acid (FeTA) is fabricated. The photothermal effect is shown to be unaffected by the template origin and type and FeTA thickness on the templates. We validate the potency of nanovesicle-supported FeTA (PNV@FeTA) for tumor-specific photoactivated utilizations, including NIR photothermal therapy with complete tumor elimination, photothermal imaging (PTI), and photoacoustic imaging (PAI) in addition to T-MRI imaging. PNV@FeTA can be simultaneously equipped with functionalities, including T-MRI imaging by additionally doping Mn and NIR fluorescence imaging by encapsulating a hydrophilic NIR fluoroprobe. MITA demonstrates unparalleled superiority as a photothermal platform in engineering multimodal theranostics for advanced applications.

In order to better constrain the paleogeographic evolution of south China we measured Sm‐Nd and Rb‐Sr isotopic compositions for 23 Mesozoic granites that crop out throughout the area. Tightly grouped neodymium depleted mantle model ages (1.4 ± 0.3 Ga) suggest the region is underlain by relatively homogeneous Proterozoic crust and fail to define crustal provinces. Neither the isotopic nor geologic data suggest that a Mesozoic suture exists. However, granites possessing anomalously high Sm (>8 ppm) and Nd (>45 ppm) concentrations, relatively high initial epsilon neodymium (−4 to −8), and high but variable initial 87Sr/86Sr (0.759 to 0.713) form a northeast trending zone that coincides with two prominent Mesozoic basins. Southeast of the zone lie the majority of Mesozoic intrusives and Upper Triassic to Lower Cretaceous extensional basins found in south China. Mesozoic paleomagnetic poles are well clustered northwest of the zone. Pre‐Cretaceous poles southeast of it are discordant with respect to those from the northwest. The only recognized tectonostratigraphic terrane in south China lies southeast of the zone. The terrane is bordered by a northeast trending sinistral fault that was active in the Mesozoic. Other faults in south China have similar attitudes, ages, and sense of shear. Together, the observations suggest that the Mesozoic tectonic regime in south China consisted of strike‐slip activity plus concomitant rifting as terranes or fragments of similar crust were transported north along sinistral faults. The zone, defined by the granites enriched in Nd and Sm, demarcates displaced terranes to the southeast from relatively stable land to the northwest.