The Covid-19 pandemic has presented health care professionals with unprecedented situations, challenges, and dilemmas in both their professional and personal lives. This brief reflective piece describes the process by which its authors experienced and reflected on working with a patient with a brain injury that emerged after receipt of a Covid-19 vaccine and was understood by the clinical team and patient to likely be vaccine related. Particular focus is given to the impact on personal risk appraisals while simultaneously holding and maintaining professional roles within an inpatient neuropsychology department, with consideration of the central role of supervision and a safe reflective space when working in highly complex areas of healthcare.