The occurrence of contrast-associated acute kidney injury (CA-AKI) is influenced by both patient-related and contrast-related factors. More specifically, CA-AKI has been linked to renal dysfunction, diabetes mellitus (DM), and atherosclerotic cardiovascular diseases (ASCVD). We hypothesized that the prevalence of CA-AKI was high in patients with diabetic foot ulcers (DFU) because they frequently have several ASCVD risk factors and additional comorbid conditions (including ASCVD). We retrospectively examined the medical records of 208 type 2 diabetic patients who were hospitalized for DFU. These patients were divided into two groups: group 1 included 107 patients who underwent contrast-enhanced computed tomographic angiography (CTA); group 2 (control group) included 101 patients who did not receive contrast media. Following CTA, 13 (12.1%) patients developed CA-AKI in group 1, while 3 (3.0%) patients in group 2 had serum creatinine elevations consistent with AKI ( P = 0.013). The following risk factors for CA-AKI were identified: longer history of DM, higher baseline serum creatinine, congestive heart failure, Wagner stage 4 and 5 DFUs, peripheral artery disease, older age, and lower hemoglobin values. CA-AKI is a common complication after CTA in patients with DFU. To reduce the risk of CA-AKI in these patients, associated risk factors and preventive measures should be considered.

Background/Aim: Malnutrition is one of the determinants of most morbidity and mortality in end-stage renal failure (ESRD) patients receiving hemodialysis (HD). Depression is the most common psychological complication among these patients. This study aimed to determine the nutritional status and anxiety-depression level in hemodialysis patients and evaluate the relationship between the two. Methods: This cross-sectional study included 55 routine hemodialysis patients over 18 years of age who were treated in the Department of Internal Diseases of a university hospital between November 2019 and January 2020. Two patients were excluded from the study due to renal transplantation. All patients filled out a two-part Hospital-Anxiety Depression Scale (HAD) and a two-part Mini Nutritional Assessment (MNA) questionnaire. The MNA-short form (MNA-SF) was first used to evaluate the malnutrition status of patients. Those who were identified as at-risk or malnourished with the MNA-SF were also asked to complete the long form. The HAD scale was used to evaluate the levels of depression and anxiety. SPSS 20 statistical package program for statistical analysis. P<0.05 was considered statistically significant. Results: The mean age of the patients was 56.2 (15.9) years; 36 (66%) were female and 18 (34%) were male. Among all, 55.8% and 26.9% of the patients were at risk in terms of depression and anxiety, respectively. Depression prevalence was higher in patients with low MNA-SF scores (P=0.001) and comorbidities (P=0.007). In those with a low MNA-SF score (P=0.001), comorbidities (P=0.008), and high urea levels (P=0.003), anxiety was more common. In patients with an elevated risk of anxiety (P=0.001) and depression (P=0.007), malnutrition risk was significantly higher. Conclusion: Depression is closely related to nutritional status in patients receiving chronic hemodialysis therapy and considered an independent risk factor for malnutrition. Early diagnosis and treatment of hemodialysis patients' psychological problems and regulation and control of nutrition programs can be practical interventions to improve the quality of life of these patients.

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lenfoma) gibi gastritle ilişkili hastalıkların en önemli nedenidir. H. pylori enfeksiyonu insanlarda sık görülen kronik bakteriyel bir enfeksiyondur (1, 2). İlk kez 1982'de iki patolog Marshall ve Waren kronik gastritli bir hastanın gastrik mukozasından spiral bir mikroorganizmayı başarılı bir şekilde kültürde üretmeyi başardı, böylece bakteri ve GİRİŞİnsan mide mukozasında gram-negatif bakteri varlığı 19. yüzyılın sonlarında tespit edilmiştir. Helicobacter pylori (H. pylori), kanserojen olduğu saptanan ilk bakteri olup dünya nüfusunun yarısından fazlasında midede kolonize olan bir patojendir. Gastrik ülser, gastrit, duodenal ülser, gastrik kanser, primer gastrik B-hücreli lenfoma (MALT Background and Aims: The eradication rate of Helicobacter pylori using standard triple therapy (amoxicillin+clarithromycin+proton pump inhibitor) as the first-line therapy has fallen below 50%. This prospective, randomized study was conducted to compare the 5+5 ( 10)-day and 7+7 ( 14)-day sequential treatment results in patients with peptic ulcer (gastric ulcer and/or duodenal ulcer) who were identified as histologically positive for Helicobacter pylori infection by gastroscopy. Materials and Methods: This study included 66 patients who had peptic ulcer diagnosed through gastroscopy, had at least two histopatholgically positive results, underwent urea breath test, had positive stool test for Helicobacter pylori antigen, and did not receive eradication therapy before. These patients were randomly divided into two groups and enrolled into the study between March 2014 and August 2015. Group 1 patients (n=33) were administered amoxicillin 1 g+esomeprazole 40 mg 2x1 for the first 5 days, followed by clarithromycin 500 mg+metronidazole 500 mg+esomeprazole 40 mg 2x1 for the next 5 days. Group 2 patients (n=33) were administered amoxicillin 1 g+esomeprazole 40 mg 2x1 for the first 7 days, followed by clarithromycin 500 mg+metronidazole 500 mg+esomeprazole 40 mg 2x1 for the next 7 days. Esomeprazole 40 mg (1x1) treatment was completed during 12 weeks in both groups. After a drug-free period of 15 days, the eradication rate was analyzed by urea breath test and Helicobacter pylori antigen stool test. Results: Ten patients in Group 1 (30.3%) were females, with a mean age of 38.0±13.1 years. Twelve patients in Group 2 (34.4%) were females, with a mean age of 39.0±15.6 years. After treatment, the urea breath test and Helicobacter pylori antigen stool test revealed an eradication rate of 70% in Group 1 and 72.7% in Group 2, with an overall eradication rate of 71.2% in all patients. No significant difference was observed between the two groups. Conclusion: At the end of the consecutive 5+5-day and 7+7-day treatment, an eradication rate of about 70% was achieved in all patients. Although not ideal, this eradication rate implies that the 5+5 (10)-day consecutive treatment could be used an alternative first-line therapy.

Araştırma Makalesi / Research Article Öz. Amaç: Kliniğimize başvuran peptik ülserli, Helikobakter Pilori (HP) pozitif hastalarda klasik üçlü tedavi verilen hastalarla klasik üçlü tedaviye bizmut eklenen hastalar arasındaki HP eradikasyon oranının karşılaştırılması amaçlanmaktadır. Materyal ve Metod: Ocak 2012-Ocak 2013 tarihleri arası prospektif olarak, endoskopilerinde gastrik ve/veya duodenal ülser (peptik ülser) saptanan, histopatoloji, üre nefes testi ya da dışkıda HP antijeni sonuçlarından herhangi birinde pozitiflik saptanan 60 hasta ardışık olarak çalışmaya alındı. Grup 1 hastalara (n=30) klasik üçlü tedavi, grup 2 hastalara (n=30) klasik üçlü tedavi+bizmut tedavileri uygulandı. 3 ay sonra her iki grubun tedavi etkinliği istatistiksel olarak karşılaştırıldı. Bulgular: Dışkıda HP antijeni saptanması testi ile grup 1' de %83,3, grup 2' de %73,3 eradikasyon olduğu belirlendi. Dışkıda HP antijeni saptanması ile yapılan değerlendirmede her iki grup arasında tedavi etkinliği açısından herhangi bir fark saptanmadı (p=0,532). Üre nefes testi ile grup 1' de %56,7, grup 2' de %53,3 eradikasyon olduğu belirlendi. Üre nefes testi ile yapılan değerlendirmede her iki grup arasında tedavi etkinliği açısından herhangi bir fark saptanmadı (p=0,795). Tüm tedavi alanlarda dışkıda HP antijeni testi ile eradike olma oranı üre nefes testine göre daha fazla görüldü, istatiksel olarak anlamlı idi (p=0,011). Sonuç: Klasik üçlü tedavi ile klasik üçlü tedavi+ bizmut tedavisi arasında eradikasyon açısından herhangi bir farklılık saptanmamıştır. Bu yüzden klaritromisin direnci göz önünde bulundurularak seçilecek tedavi ona göre belirlenmelidir. Ayrıca tedavi sonrası etkinliği değerlendirmede dışkıda HP antijeni testi ile üre nefes testi arasında anlamlı fark bulunup dışkıda HP antijeni ile eradikasyon oranı daha yüksek görünmektedir.