Purpose of Review Prostate cancer is one of the most common cancers in men and accounts for about 10% of all new cancer cases in the USA. Despite significant improvements in survival, it is estimated that deaths from prostate cancer in 2019 will exceed 30,000 individuals. Here, we review plant-derived bioactive compounds with the ability to modulate the growth of prostate cancer cells. These compounds represent potential therapeutic alternatives for the prevention and treatment of prostate cancer. Recent Findings Numerous plants produce phytochemicals that are important for their development and protection. Many of these compounds have inhibitory effects on the growth of cancer cells. Summary Cancers are a leading cause of death worldwide and treatments tend to be costly with many negative side effects. Identification of new potential chemo-therapeutic and chemo-protective compounds that have little or no negative effects on normal cells is therefore of great importance.