The synthesis, characterization and properties of pH/thermosensitive hydrogels based on acrylic acid (AAc) and N-isopropylacrylamide (NIPA) using (+)-N,N'-diallyltartramide (DAT) as cross-linking agent and water as solvent, are presented in this article. Subsequently, the incorporation of ofloxacin (OFL) as model drug to evaluate the drug load capacity of hydrogels and the in vitro release from OFL-polymer conjugate are presented in order to define potential pharmaceutical applications. Interestingly, the incorporation of AAc diversified the properties of NIPA-based hydrogels allowing ionic interaction of these new materials with drugs of opposite charge and produced different release profiles at pH 1.2 and 6.8 simulated physiological media.

a b s t r a c tSuperhydrophobic nanocomposite coatings on injection-molded polypropylene (PP) samples were prepared by dipping in xylene solvent containing titanium dioxide nanoparticles (NPs) functionalized with trimethoxypropyl silane. Alternatively, PP samples were dipped in a mixture of functionalized NPs and dissolved PP pellets. As a general result, dip-coated PP samples reached a permanent superhydrophobic state with a contact angle hysteresis (CAH) depending on NPs concentration and surface chemistry. SEM and profilometer measurements show a general trend in the decrease of CAH with the increase of aggregates and roughness. However some results showed that surfaces with the same roughness presented different CAHs. XPS measurements showed that low CAHs and self-cleaning properties were obtained only when the Ti-OH relative concentration on the surface was about 20%. At higher Ti-OH relative concentrations, the surface kept a superhydrophobic static state but lost its self-cleaning properties. This work highlights the fact that both control of the roughness together with chemical surface composition of polar groups have to be taken into account for a precise tuning on the superhydrophobic dynamic component of the surface.