Resveratrol, in vitro and at low concentration, modulates genes that are related to lipid metabolism, possibly preventing metabolic disease in human visceral adipose tissue (VAT).

Downregulation of SIRT1 mRNA expression in VAT of SHS could be possible impairing mitochondria biogenesis and fatty acid oxidation, promoting severe steatosis in obese patients. Our results provide a possible proof of SIRT1 protective potential in VAT against NAFLD in humans.

Objective: Adipose tissue is responsible for secretion of several cytokines that mediate systemic effects on obesity and insulin resistance. Subcutaneous abdominal adipose tissue (SAT) and visceral adipose tissue (VAT) are metabolically different and have differences in their gene expression profile. Our study evaluated the expression of adiponectin, FOXO1, PPARγ, and SIRT1 in VAT and SAT of non-obese and class III obese subjects. Methods: The adipose tissue samples were obtained by surgery. Reverse transcripts of studied genes were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Results: Comparing the different lipid depots, adiponectin expression was lower only in VAT of obese individuals (p = 0.043); FOXO1 and PPARγ levels were decreased in VAT of both groups. When non-obese and obese were compared, only adiponectin expression was lower in SAT and in VAT of obese subjects (p = 0.004 and p = 0.002, respectively). No difference was found with regard to SIRT1 levels in VAT or SAT in both groups. FOXO1 expression in SAT of obese subjects had a negative correlation with age (r = –0.683; p = 0.029) and triglyceride serum levels (r = –0.794; p = 0.006). Conclusion: The decrease mRNA expression of this genes in VAT, responsible for central adiposity, may be associated with an increased risk of obesity and co-morbidities.

ObjetivoNeste estudo, objetivou-se investigar a prevalência de infecções parasitárias entre crianças de 12 a 16 meses atendidas em Unidades de Saúde de Porto Alegre, Rio Grande do Sul.MétodosO estudo consistiu na análise de dados socioambientais e inquérito parasitológico de crianças que participaram de um ensaio de campo randomizado por conglomerados.ResultadosA renda familiar total mensal encontrada era menor que três salários-mínimos em 79,0% dos casos. Um total de 43,7% das mães e 47,5% dos pais relatou tempo de estudo menor que 8 anos. Em 4,4% dos domicílios não havia serviço de esgoto e em 5,5% o banheiro era localizado na área externa. Apesar da baixa condição socioeconômica encontrada na população do estudo, a prevalência de parasitose foi de 6,8% do total da amostra.ConclusãoOs resultados per-mitem concluir que as crianças na faixa etária estudada não constituem grupo de risco para infestação parasitária.Termos de indexação: Parasita. Bem-estar da criança. Criança.

The first author's middle initial was incorrectly captured in the original publication. The correct name is Costa, C. S.