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IntroductionIn 2016, due to the vulnerability to IST/HIV/AIDS of young people deprived of their liberty, a partnership was established between the STD/AIDS Referral and Training Centre (CRT-DST/Aids, of the Health Secretariat of the State of São Paulo), the Centre for Socio-educational Assistance to Adolescents (CASA) Foundation and UNICEF with the objective to carry out integrated prevention actions with the employees of the Foundation and with the youngsters.MethodsThe actions included training, reflections, improvement of STI approaches and treatment with emphasis on syphilis, and access to prevention inputs (male and female condoms and HIV, syphilis, hepatitis B and C testing). A workshop was held with the employees of the Ruth Pistori Women’s Unit with the participation of the State Network of Young People Living with HIV/AIDS and representatives of the state in the Health Popular Education Movement. The aim was that the script of the talks were prepared by the staff of the CASA Foundation under the supervision of technicians of the STD/Aids State Program and that they apply to the unit every fortnight so that all the girls could have access to the information and thoughts about combined prevention.ResultsIn October 2016, were held five Talking Groups with the participation of all 75 girls who were at the Centre at that time. The girls have built murals with prevention ways so they are posted in strategic locations and in classrooms. After the reflections, all the girls wanted to carry out the tests for HIV, hepatitis B and C and Syphilis. The Centre is developing Talking Groups with the girls every fortnight.ConclusionThis experience shows that it is possible to carry out continuous prevention actions at the CASA Foundation’s deprivation of liberty units and to work with other forms of prevention besides the use of condoms. So, a Prevention Program for Syphilis with a specific protocol for diagnosis and treatment will be elaborate in 2017 in order to be implemented in all CASA Foundation units.