Beta vulgaris also known as beet root has been used to treat a wide range of symptoms and diseases, such as fever, constipation, cancer, diabetes, liver and heart diseases. The aim of this study was to investigate the protective ability of beta vulgaris on the liver following Carbon tetrachloride (CCl4) intoxication. Twenty five adult albino wistar weighing between 150g and 200g were used in this study. The animals were divided into five groups A, B, C, D, and E. Groups A and B served as control were injected with paraffin oil for two consecutive days and group B fed with Beta vulgaris extract alone. Groups C and D were injected with CCl4 (1.0ml/kg b.w i.p) for two consecutive days and group D fed with BE throughout the experimental days. Group E was fed with Beta vulgaris extract throughout the experiment and injected CCl4 on the last two days of the experimental period (28 days).
At the end of the experimental period animals were reweighed and sacrificed using chloroform vapour. Blood was collected for serum enzyme analysis and liver was harvested and trimmed for histological studies. The result showed that, there was a decrease in mean body weight of 5% in group C animals while there was an increase in other groups. The liver weight were significantly higher in group C (p<0.05) when compared with control groups and other experimental groups. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in group C were significantly higher (p<0.05) when compared with the control group while groups B, D and E were normal.
Histological examination of liver (H&E) showed numerous fatty changes, distortion of hepatocytes, focal necrosis, loss of nuclei and cytoplasmic shrinkage in group C animals, groups A, B and E appear normal, while group D showed mild focal inflammation and areas of regeneration of tissues
These results shows that Beta vulgaris extract has the ability to prevent and also restore histological and biochemical changes in the liver following CCl4 injection.
This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Background: The degree of physical activity may induce strain and stress on the Achilles tendon because of its role in the elastic mechanics of gait. Material &Methods: The study was carried out to determine the effect of occupation-related physical activity on the thickness of the Achilles tendon. The effect of occupation- related physical activity on the thickness of the Achilles tendon in three phases (ATT at Normal phase, ATT at Dorsiflexed phase and ATT at Plantarflexed phase) was assessed, by ultrasound, among four classes of occupations- Labourers/farmers, Dancers, Athletes and a less active class (control group). Results: Results show that the less active (control group) had the least value for ATT (normal) (3.31±0.50mm) being almost at par with those of the dancers. The athletes and labourers/farmers had significantly higher values than the control (P=0.000 and 0.007 respectively). Conclusion: Our findings have conclusively established that occupation-related prolonged physical activity induces thickening of the Achilles tendon. DOI: http://dx.doi.org/10.3329/bjms.v11i2.9666 Bangladesh Journal of Medical Science Vol. 11 No. 02 April 2012: 103-111
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