The mechanisms of action of silver nanoparticles (AgNPs) in monogenean parasites of the genus Cichlidogyrus were investigated through a microarray hybridization approach using genomic information from the nematode Caenorhabditis elegans. The effects of two concentrations of AgNPs were explored, low (6 µg/L Ag) and high (36 µg/L Ag). Microarray analysis revealed that both concentrations of AgNPs activated similar biological processes, although by different mechanisms. Expression profiles included genes involved in detoxification, neurotoxicity, modulation of cell signaling, reproduction, embryonic development, and tegument organization as the main biological processes dysregulated by AgNPs. Two important processes (DNA damage and cell death) were mostly activated in parasites exposed to the lower concentration of AgNPs. To our knowledge, this is the first study providing information on the sub-cellular and molecular effects of exposure to AgNPs in metazoan parasites of fish.
En los océanos existen un grupo amplio y diverso de pequeños crustáceos acuáticos, los copépodos. Aunque no podemos verlos a simple vista, son muy importantes para mantener el equilibrio de los nutrientes y energía en los mares. Sin embargo, los efectos del cambio climático, como el aumento de la temperatura en el mar, puede afectar a los copépodos. Varios estudios han demostrado que se pueden alterar funciones como en la reproducción, el desarrollo, crecimiento y en casos graves pueden hasta morir. El estudio de los copépodos nos ha dado pistas para predecir los efectos del cambio climático en los océanos. Por eso es interesante conocer más sobre los copépodos y su relación con el cambio climático.
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