NSAIDs use during acute viral infection is associated with an increased risk of empyema in children, and antibiotics are associated with a decreased risk. The presence of antibiotic-NSAIDs interaction with this risk is suggested. These findings suggest that NSAIDs should not be recommended as a first-line antipyretic treatment during acute viral infections in children.

The objective of this study is to investigate the motion of an ellipsoidal capsule in a simple shear flow when its revolution axis is initially placed off the shear plane. We consider prolate capsules with an aspect ratio of two or three enclosed by a membrane, which is either strain-hardening or strain-softening. We seek the equilibrium motion of the capsule as we increase the capillary number $\mathit{Ca}$, which measures the ratio between the viscous and elastic forces. The three-dimensional fluid–structure interaction problem is solved numerically by coupling a boundary integral method (for the internal and external flows) with a finite element method (for the wall deformation). For any initial inclination with the flow vorticity axis, a given capsule converges towards a unique equilibrium configuration which depends on $\mathit{Ca}$. At low capillary number, the stable equilibrium motion is the rolling regime: the capsule aligns its long axis with the vorticity axis, while the membrane tank-treads. As $\mathit{Ca}$ increases, the capsule takes a complex wobbling motion at equilibrium, precessing around the vorticity axis. As $\mathit{Ca}$ is further increased, the capsule long axis oscillates about the shear plane, while the membrane rotates around a capsule cross-section that also oscillates over time (oscillating–swinging regime). The amplitude of the oscillations about the shear plane decreases as $\mathit{Ca}$ increases and the capsule finally takes a swinging motion in the shear plane. It is found that the transitions from rolling to wobbling and from wobbling to oscillating–swinging depend on the mean energy stored in the membrane.