Background. The integration of a life environment enabling people with autism spectrum disorder (ASD) to fully exercise their independence must be well prepared. Purpose. Review and describe interventions intended to develop the independence at home of people with ASD. Method. The PRISMA method was used to perform a systematic review based on 19 keywords, grouped under three concepts: (a) population age (adolescents and adults), (b) diagnosis (ASD), and (c) independence. Findings. Seven effective interventions were identified in the 20 selected articles: (a) video self-modeling, (b) video modeling, (c) behavioural interventions, (d) video prompting, (e) transition planning program, (f) training in the use of a cognitive aid, and (g) social skills group. Implications. The results of this review will help guide practitioners in the implementation of interventions that foster the development of independence at home of people with ASD.