No abstract

In 2005, the Moser group identified a new type of cell in the entorhinal cortex (ERC): the grid cell (Hafting, Nature, 436, 2005, pp. 801-806). A landmark series of studies from these investigators showed that grid cells support spatial navigation by encoding position, direction as well as distance information, and they subsequently found grid cells in pre-and para-subiculum areas adjacent to the ERC (Boccara, Nature Neuroscience, 13, 2010, pp. 987-994). Fast forward to 2010, when some clever investigators developed fMRI analysis methods to document grid-like responses in the human ERC (Doeller, Nature, 463, 2010, pp. 657-661). What was not at all expected was the co-identification of grid-like fMRI responses outside of the ERC, in particular, the orbitofrontal cortex (OFC) and the ventromedial prefrontal cortex (vmPFC). Here we provide a compact overview of the burgeoning literature on grid cells in both rodent and human species, while considering the intriguing question: what are grid-like responses doing in the OFC and vmPFC?

No abstract