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This questionnaire helped to identify a group at high risk for melanoma. Furthermore, good agreement was found when the patient's risk scores were compared with results of the clinical skin examination. This risk score is potentially useful in targeting primary and secondary prevention of melanoma through general practice.

Low dose rate brachytherapy High dose rate brachytherapy External beam radiotherapy a b s t r a c t Introduction: There is evidence to support use of external beam radiotherapy (EBRT) in combination with both low dose rate brachytherapy (LDR-EBRT) and high dose rate brachytherapy (HDR-EBRT) to treat intermediate and high risk prostate cancer. Methods: Men with intermediate and high risk prostate cancer treated using LDR-EBRT (treated between 1996 and 2007) and HDR-EBRT (treated between 2007 and 2012) were identified from an institutional database. Multivariable analysis was performed to evaluate the relationship between patient, disease and treatment factors with biochemical progression free survival (bPFS).Results: 116 men were treated with LDR-EBRT and 171 were treated with HDR-EBRT. At 5 years, bPFS was estimated to be 90.5% for the LDR-EBRT cohort and 77.6% for the HDR-EBRT cohort. On multivariable analysis, patients treated with HDR-EBRT were more than twice as likely to experience biochemical progression compared with LDR-EBRT (HR 2.33, 95% CI 1.12-4.07). Patients with Gleason 8 disease were more than five times more likely to experience biochemical progression compared with Gleason 6 disease (HR 5.47, 95% CI 1.26-23.64). Cumulative incidence of grade 3 genitourinary and gastrointestinal toxicities for the LDR-EBRT and HDR-EBRT cohorts were 8% versus 4% and 5% versus 1% respectively, although these differences did not reach statistical significance. Conclusion: LDR-EBRT may provide more effective PSA control at 5 years compared with HDR-EBRT. Direct comparison of these treatments through randomised trials are recommended to investigate this hypothesis further.

A prospective survey of 3105 adults in 16 randomly selected group practices was conducted to test whether individuals with a personal experience, family history, or other contact with malignant melanoma display more knowledge and appropriate behavior with regard to melanomas and sun exposure than those with no such experience. Although patients with previous contact with the condition were more likely to check for moles, were more aware of the significance of changes in the shape of moles, and were more aware of the necessity for prompt treatment, they were not more knowledgeable about other important signs or more likely to protect themselves from sun exposure. Direct experience or contact with melanoma appeared to have some positive effects on knowledge, but there is no room for complacency for those at increased risk or those treating them. Both primary and secondary prevention for people who are vulnerable could be undertaken in primary care.

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