No abstract

Two consecutive, randomized, double-blind trials were performed to test the analgesic properties of a synthetic nitrogen analog of tetrahydrocannabinol (NIB). In the first trial, the test preparation was superior to placebo and approximately equivalent to 50 mg of codeine phosphate. In the second study, the tetrahydrocannabinol analog was superior to placebo and to 50 mg secobarbital. NIB is not useful clinically because of the frequency of side effects.

No abstract

SUMMARYThirty-three patients with severe hypertension were treated with rapidly injected intravenous diazoxide. Renal function was measured in nine patients and four underwent cardiac catheterization during renal function studies. Diazoxide had a rapid, profound hypotensive effect. Average Thirty-three patients with severe or malignant hypertension were studied. All patients had sustained diastolic blood pressures of 120 mm Hg or more. The patients were separated into two groups.Group 1 consisted of 24 patients, age 10 months to 57 years, who were studied clinically. Many had severe renal disease. Mean blood urea nitrogenwas 82 mg% and mean serum creatinine was 7.7 mg%. The patients were given 300 mg of diazoxide intravenously by the rapid-injection technique described by Finnerty The intra-aortic systolic, diastolic, and mean blood pressure, before, during, and after rapid intravenous injection of 300 mg of diazoxide.