A novel method for the electrochemical dissolution of polyelectrolyte multilayers from the surface of an electrode for applications in controlled drug delivery is reported. Biodegradable and biocompatible multilayer films based on poly(L‐lysine) and heparin have been selected as a model system, and have been built on an indium tin oxide semiconductor substrate. The build‐up and dissolution processes of the multilayers is followed by electrochemical optical waveguide light mode spectroscopy. The formation and stability of the polyelectrolyte multilayers have been found to depend on the applied potential and the ionic strength of the buffer. The application of potentials above a threshold of 1.8 V induces dissolution, which follows single‐exponential kinetics, of the polyelectrolyte multilayer film. The rate of this process can be varied by an on–off profile of the potential, leading to the controlled release of heparin into the bulk. Atomic force microscopy investigations show that the electrodissolution of the polyelectrolyte multilayers is a local phenomenon that leads to the formation of nanoporous films.
A novel method for non‐invasive cell sheet recovery based on polyelectrolyte thin films is presented. Coatings with highly tunable properties allow for controlling the cell surface interactions or can be used as electronically switchable sacrificial layer offering a promising new tool for cell sheet based tissue engineering.
Our findings suggest the need to conduct longitudinal studies to give proper consideration to the temporal aspect of caries development and clarify the results obtained by on the relationship between parenting stress and oral health. Further study is also warranted to more clearly elucidate the association between social desirability (defensive responding) in parents and their children's ECC experience.
The creation of geometrically well-defined submicron structures on insulating substrates by
e-beam lithography is hampered by surface charging. This problem becomes crucial when
trying to create nanosized protein patterns by selective molecular assembly patterning
(SMAP) on transparent glass substrates. In this paper we demonstrate that the use of thin
films of conductive indium tin oxide resolves the issue of surface charging during e-beam
writing while being compatible with the standard SMAP protocol for surface modification.
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