A new fluorous analogue of the popular MOM (methoxymethyl) protecting group can be introduced by reactions of alcohols with 1H,1H,2H,2H,3H,3H-perfluoroundecyloxymethyl chloride (C 8 F 17 (CH 2 ) 3 OCH 2 Cl) and the resulting fluorous methoxymethyl ( F MOM) adducts can be deprotected under Brønsted or Lewis acidic conditions. The results suggest that the F MOM protecting group will find use in a number of fluorous synthesis settings.

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