The trend of e-cigarette use among teens is ever increasing. Here we show the dysbiotic oral microbial ecology in e-cigarette users influencing the local host immune environment compared with non-smoker controls and cigarette smokers. Using 16S rRNA high-throughput sequencing, we evaluated 119 human participants, 40 in each of the three cohorts, and found significantly altered beta-diversity in e-cigarette users (p = 0.006) when compared with never smokers or tobacco cigarette smokers. The abundance of Porphyromonas and Veillonella (p = 0.008) was higher among vapers. Interleukin (IL)-6 and IL-1b were highly elevated in e-cigarette users when compared with non-users. Epithelial cell-exposed e-cigarette aerosols were more susceptible for infection. In vitro infection model of premalignant Leuk-1 and malignant cell lines exposed to e-cigarette aerosol and challenged by Porphyromonas gingivalis and Fusobacterium nucleatum resulted in elevated inflammatory response. Our findings for the first time demonstrate that e-cigarette users are more prone to infection.

Introduction: Tobacco use is one of the main causes of periodontitis. E-cigarette are gaining in popularity, and studies are needed to better understand the impact of e-cigarettes on oral health.Objective: To perform a longitudinal study to evaluate the adverse effects of e-cigarettes on periodontal health.Methods: Naïve E-cigarette users, cigarette smokers, and non-smokers were recruited using newspaper and social media. Age, gender, and ethnicity, were recorded. Participants were scheduled for two visits 6 months apart. At each visit, we collected data on the frequency and magnitude of e-cigarette and cigarette use, and alcohol consumption. Carbon monoxide (CO) levels, cotinine levels, salivary flow rate, periodontal probing depth (PD), bleeding on probing (BoP), and clinical attachment loss (CAL) were also determined at both baseline and follow-up visits and compared between groups with two-way repeated measures ANOVA. Periodontal diagnosis and other categorical variables were compared between groups with the chi-square statistic and logistic regression.Results: We screened 159 subjects and recruited 119 subjects. One-hundred-one subjects (31 cigarette smokers, 32 e-cigarette smokers, and 38 non-smokers) completed every assessment in both visits. The retention and compliance rate of subjects was 84.9%. The use of social media and craigslist was significant in recruiting e-cigarette subjects. Ethnicity and race differed between groups, as did average age in the male subjects. Carbon monoxide and salivary cotinine levels were highest among cigarette smokers. Bleeding on probing and average PDs similarly increased over time in all three groups, but CAL uniquely increased in e-cigarette smokers. Rates of severe periodontal disease were higher in cigarette smokers and e-cigarette users than non-smokers, but interpretation is confounded by the older age of the cigarette smokers.Conclusion: Among the recruited participants, CAL after 6 months was significantly worse only in the e-cigarette smokers. This study design and protocol will assist in future larger studies on e-cigarette and oral health.

El virus SARS-CoV-2 causante de la enfermedad COVID-19 es altamente contagioso y debido a que la propagación nosocomial ha sido bien documentada, se han implementado directrices que incluyen el uso de elementos de pro­tección personal (EPP) con el objetivo de minimizar el riesgo de contagio en el personal de la salud. Secundario al uso continuo, repetitivo y prolongado de estos dispositivos, se pueden desencadenar procesos inflamatorios cutáneos tales como: dermatitis de contacto, prurito o urticaria por presión, o exacerbar procesos inflamatorios preexistentes como dermatitis seborreica, acné, entre otros. Por lo anterior, la Asociación Colombiana de Derma­tología y Cirugía Dermatológica (AsoColDerma), en alianza con el Hospital Universitario Centro Dermatológico Federico Lleras Acosta, como ente asesor del Gobierno colombiano, nos permitimos hacer las siguientes recomen­daciones encaminadas a reducir el riesgo de lesiones cutáneas derivadas del uso de los equipos de protección personal. Estas recomendaciones son de orientación general para la práctica clínica, y el personal de la salud las debe se­guir de forma individualizada, de acuerdo con sus necesidades y con los recursos disponibles.

The eccrine poroma or Hidracanthoma Simplex is a rare benign adnexal tumor of epithelial cells, with an incidence of 0.001 to 0.008%1. In 2/3 of the patients it appears on the soles and lateral borders of the feet. We report the case of a patient with pigmented eccrine poroma in abdominal skin, of a rare entity presentation with a single report in the literature in that location.

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