Calcium phosphate cements are known for their biocompatibility and bioactivity, which has led to a significant increase in their use. They have the advantage of being prepared as a malleable paste that sets in a few minutes and can be easily applied in bone defects. In this research work, 6 brushite cement formulations were prepared and the effect of collagen addition and the release of tetracycline were evaluated. All cements gave a malleable paste that set in 2 or 3 min, resulting in a material with pores of 5–20 μm. The cements showed compression resistance values between 0.8 and 1.7 MPa, and the addition of collagen was the most influential factor in the increase of this property. Up to 40 % of the drug was released after 7 days and the effectiveness of its antimicrobial activity was confirmed.

Calcium phosphate cements have the advantage that they can be prepared as a paste that sets in a few minutes and can be easily adapted to the shape of the bone defect, which facilitates its clinical application. In this research, six formulations of brushite (dicalcium phosphate dihydrated) cement were obtained and the effect of the addition of sodium alginate was analyzed, such as its capacity as a tetracycline release system. The samples that contain sodium alginate set in 4 or 5 min and showed a high percentage of injectability (93%). The cements exhibit compression resistance values between 1.6 and 2.6 MPa. The drug was released in a range between 12.6 and 13.2% after 7 days. The antimicrobial activity of all the cements containing antibiotics was proven. All samples reached values of cell viability above 70 percent. We also observed that the addition of the sodium alginate and tetracycline improved the cell viability.