Background: Substance use is a presumed risk factor for Alzheimer's Disease (AD).So, it would be essential to evaluate it in people who already have a high risk of dementia. Neuroscience Group of Antioquia, GNA, is a research group from Medellin, Colombia, which studies Presenilin 1 (PS1) E280A mutation carriers. These carriers will course four stages of AD: 1) asymptomatic Pre-Mild Cognitive Impairment (Pre-MCI),2) symptomatic pre-MCI, 3) MCI; and 4) Dementia. Substance consumption could modify age-at-onset of those stages, but this association has not been deeply explored.