Type 2 Diabetes Mellitus (T2DM) is considered a public health problem worldwide. Current treatment involves the use of oral antidiabetics, whereas natural products could be a therapeutic alternative because of their bioactive compounds. The objective of this research was to investigate the chemical pro le and antidiabetic effect of the peel of Annona squamosa L. (sugar apple) and evaluate a possible mechanism of action. We analyzed the content of secondary metabolites nding the following in 100 g of freeze-dried peel: 5000.

Type 2 Diabetes Mellitus (T2DM) is considered a public health problem worldwide. Current treatment involves the use of oral antidiabetics, whereas natural products could be a therapeutic alternative because of their bioactive compounds. The objective of this research was to investigate the chemical profile and antidiabetic effect of the peel of Annona squamosa L. (sugar apple) and evaluate a possible mechanism of action. We analyzed the content of secondary metabolites finding the following in 100 g of freeze-dried peel: 5000.13 ± 30.44 GAEq mg, 82.04 ± 1.12 QEq mg, 3023.07 ± 75.83 AA mg, 13919.07 ± 492.11 CA mg, 16099.56 ± 492.11 L-MA mg, 21346.73 ± 1134.01 D-MA mg, 5261.92 ± 34.59 TA mg, 2920.15 ± 290.13 Glu mg, and 5271.59 ± 562.07 Fru mg. The antihyperglycemic effect of the freeze-dried peel of sugar apple was demonstrated using an Oral Glucose Tolerance Test (OGTT) in healthy Wistar rats, discovering an effect at doses of 100 and 200 mg/kg, which was reversed by administering Wortmannin at 1 mg/kg. Regarding the antidiabetic effect in a T2DM model after 14-days of treatment, we found a decrease in non-fasting glucose, and capillary glucose levels during an OGTT, as well as an improvement in insulin response. These results allow us to conclude that sugar apple peel has a beneficial effect on the regulation of glucose levels in both healthy and diabetic rats, seemingly to be related to the insulin signaling pathway; therefore, this could be an alternative therapy for glucose control in prediabetes and T2DM