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The implementation of a fully instrumented, automated and simulation-enabled engineering software platform capable of automating the currently still manual model-based systems engineering (MBSE) design process for physical systems architecture generation and optimization in an aircraft wing is presented. The software platform uses graph-based design languages to integrate and entirely automate the mainly manual packing, piping and harness routing design. This design automation and optimization is achieved by a novel software stack of an optimization software coupled with a design compiler. It is shown that through rule-based model generation by a design compiler in the form of a design graph as a central data model, a cross-domain data consistency is achieved. This allows for automated execution and coupling of engineering tasks over several different domains such as packing, piping and routing design to converge to an optimized wing physical architecture design variant in agreement with given predetermined design constraints.