The effect of converting ammonium into guanidine moieties, compared to other factors such as molecular weight or hydrophobicity, on the antibacterial activity is investigated for homo- and copolymers of 2-aminoethylmethacrylate in solution or coatings. Polymers are obtained by free radical polymerization, polymer-analogous guanidinylation is conducted with cyanamide; non-leaching immobilization is achieved by LBL assembly of homopolymers or crosslinking of functional sidegroups in copolymers. Antibacterial activity to Escherichia coli or Bacillus subtilis is determined by different standard methods. Guanidinylation improves antibacterial activity and speed as well as cytotoxicity of hydrophilic homo- and copolymers in solution or coatings.

Summary This study describes newly developed mathematical models of bottle rinsing. Our approach is based on 3D‐CFD models of turbulent two‐phase flow (water and air), which have been implemented based on the freely available open source software OpenFOAM. The models are validated using data obtained with a standard injection nozzle and then used to evaluate the performance of two fictitious modified nozzle types w.r.t. cleaning efficiency, water consumption and water drainage. Maps of the interior walls of the bottles showing the distribution of important parameters such as wall shear stresses or water coverage were derived from the simulations. The simulations suggest that rotating or pulsating injection nozzles may perform better than standard nozzle configurations.

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