Introduction: Chronic Obstructive Pulmonary Disease (COPD) promotes inactivity generating impairment of exercise capacity by reducing muscle mass, causing, in addition to pulmonary manifestations, systemic effects such as involuntary weight loss and muscle dysfunction. In this context, Pulmonary Rehabilitation Programs (PRP), have shown beneficial effects on exercise capacity and symptoms in COPD patients. Objective: To analyze the functional capacity of patients with COPD through the six-minute walk test (6MWT) in the pre and post PRP phases. Methodology: This is an analytical, longitudinal, prospective and quantitative clinical trial, of a local scale, in which five patients with a mean age of 70.8 ± 6.06 with COPD, underwent a PRP. Before and after PRP, functional capacity was assessed using the 6MWT. The statistical treatment of the data was performed using the SPSS 19.0 Statistical Package, Student's t test was applied. A significance level of p <0.05 was adopted. Result: The therapy adopted with the sample was not able to promote significant statistical changes (p = 0.11) in the distance covered in the 6MWT. Conclusion: Although there was a slight increase in the distance covered in the 6MWT after PRP, there was no statistically significant change in the functional capacity of patients with COPD.
Objetivo: Analisar a frequência de micronúcleos em células da mucosa oral de pacientes com doença pulmonar obstrutiva crônica (DPOC), submetidos a um programa de reabilitação pulmonar (PRP). Metodologia: Estudo quase experimental, quantitativo, prospectivo, não controlado, no qual sete participantes com diagnóstico clínico e espirométrico de DPOC, foram submetidos a 20 sessões de um PRP, realizado em 7 semanas contínuas. Para classificar o estágio da doença, realizou-se o exame de espirometria antes de iniciar o protocolo. Para a quantificação de micronúcleos, antes e após o PRP foi realizado o teste de micronúcleo na mucosa oral. Para analisar os dados coletados, aplicou-se o teste de Shapiro Wilk para verificar a normalidade das variáveis e o teste Wilcoxon para comparação antes e depois, adotando-se um nível de significância p≤0,05. Resultados: Observou-se redução significativa (p=0,043) na frequência de micronúcleos em células epiteliais da mucosa oral após a aplicação do PRP. Conclusão: A diminuição da frequência de micronúcleos no pós-tratamento permite sugerir que os participantes obtiveram diminuição dos danos no DNA quando submetidos ao PRP, no entanto, ensaios controlados e randomizados devem ser realizados para elucidar os efeitos do treinamento físico sobre o caráter genético de pacientes com DPOC.
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