Objectives Dietary factors may play a role in uterine fibroids etiology due to their potential to modify endogenous hormones and their inflammatory effects – these processes may be influenced by food contaminants including pesticides. We sought to examine the association between pesticide residue intake from consumption of fruits and vegetables and risk of ultrasound or hysterectomy-confirmed fibroids. Methods A prospective cohort study using data collected from 52,982 premenopausal women from 1999–2009 in the Nurses’ Health Study II. Every four years, diet was assessed with a validated food frequency questionnaire. We classified fruits and vegetables into high- or low-pesticide-residues using a validated method based on surveillance data from the U.S. Department of Agriculture. Multivariable Cox proportional hazards models were used to calculate RR and 95% CIs for the association between high- and low-pesticide-residue fruit and vegetable intake and fibroids. Results During 10 years of follow-up (median age at baseline 42 years), 4,285 incident cases of ultrasound or hysterectomy-confirmed fibroids were reported. No association was observed between intake of high-pesticide-residue (RR for 5th vs 1st quintile = 0.91; 95% CI = 0.80–1.03; ptrend = 0.12) nor the low-pesticide-residue (RR for 5th vs 1st quintile = 1.01; 95% CI = 0.88–1.14; ptrend = 0.84) fruits and vegetables and fibroids. Conclusions No clear associations were observed between intake of high- or low-pesticide-residue fruits and vegetables and risk of uterine fibroids. These results suggest that pesticide residues on fruits and vegetables are not strong contributors to fibroid risk among women in their 30s, 40s, and 50s. Additional studies examining an exposure window more proximal to fibroid initiation among younger women and assessing class specific pesticides are needed. Funding Sources National Institutes of Health.

Background: Genital powder use is more common among African-American women; however, studies of genital powder use and ovarian cancer risk have been conducted predominantly in White populations, and histotype-specific analyses among African-American populations are limited. Methods: We used data from five studies in the Ovarian Cancer in Women of African Ancestry consortium. Participants included 620 African-American cases, 1,146 African-American controls, 2,800 White cases, and 6,735 White controls who answered questions on genital powder use prior to 2014. The association between genital powder use and ovarian cancer risk by race was estimated using logistic regression. Results: The prevalence of ever genital powder use for cases was 35.8% among African-American women and 29.5% among White women. Ever use of genital powder was associated with higher odds of ovarian cancer among African-American women [OR = 1.22; 95% confidence interval (CI) = 0.97–1.53] and White women (OR = 1.36; 95% CI = 1.19–1.57). In African-American women, the positive association with risk was more pronounced among high-grade serous tumors (OR = 1.31; 95% CI = 1.01–1.71) than with all other histotypes (OR = 1.05; 95% CI = 0.75–1.47). In White women, a significant association was observed irrespective of histotype (OR = 1.33; 95% CI = 1.12–1.56 and OR = 1.38; 95% CI = 1.15–1.66, respectively). Conclusions: While genital powder use was more prevalent among African-American women, the associations between genital powder use and ovarian cancer risk were similar across race and did not materially vary by histotype. Impact: This is one of the largest studies to date to compare the associations between genital powder use and ovarian cancer risk, overall and by histotype, between African-American and White women.

PURPOSE: To date, the epidemiology of epithelial ovarian cancer (EOC) among African-American women has been severely understudied. It remains unclear to what extent variation in the prevalence of EOC risk factors may explain incidence disparities between African-American and white women. Genital powder use is more common among African-American women; however, studies of genital power use and EOC risk have been conducted predominantly in white populations, and histotype specific analyses among African-American populations are limited. The objective of this study was to evaluate the association between genital powder use and EOC risk among African-American and white women, overall and by histotype. METHODS: We used data from four ovarian cancer case-control studies in the Ovarian Cancer in Women of African Ancestry (OCWAA) consortium: the African American Cancer Epidemiology Study, the Los Angeles County Ovarian Cancer Study, the Cook County Case-Control Study, and the North Carolina Ovarian Cancer Study. Participants included 601 African-American cases, 1,012 African-American controls, 2,225 white cases, and 3,086 white controls who answered questions on genital powder use prior to 2014. The association between genital powder use and EOC risk was estimated using logistic regression. Pooled histotype specific odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using polytomous logistic regression. The population attributable risk (PAR) by race was calculated using the Bruzzi method. RESULTS: The prevalence of reporting ever genital powder use was 66% among African-American women and 44% among white women. African- American women who ever used genital powder were 29% more likely to develop EOC compared to African-American women who reported no use (OR=1.29, 95% CI=0.98-1.71). White women who ever used genital powder were 36% more likely to develop EOC compared to white women reporting no use (OR=1.36, 95% CI=1.12- 1.52). The associations were similar when examined by histotype. Among African- American women, the ORs were 1.29 (95% CI=0.94-1.76) for high grade serous (HGS) and 1.38 (95% CI=0.87-2.19) for non-HGS. For white women, the corresponding ORs were 1.27 (95% CI=1.06-1.52) and 1.21 (95% CI=0.96-1.56), respectively. The PAR for genital powder use was slightly higher, but not statistically significantly different, in African-American women (PAR=10.7, 95% CI=3.7-17.5) compared to white women (PAR=7.8, 95% CI=4.9-10.7). CONCLUSION: While the prevalence of ever genital body powder use was higher among African-American women, the associations between genital powder use and ovarian cancer risk were similar between African-American and white women, and did not materially vary by histotype. Further analyses incorporating additional OCWAA studies and using more refined exposure categories (e.g., frequency and duration of powder use, age at first application) are currently being conducted. Citation Format: Colette P. Davis, Elisa V. Bandera, Traci N. Bethea, Tareq F. Camacho, Charlotte E. Joslin, Anna H. Wu, Alicia Beeghly-Fadiel, Emily K. Cloyd, Patricia G. Moorman, Evan Myers, Heather M. Ochs-Balcom, Lauren C. Peres, Will L. Rosenow, Veronica W. Setiawan, Lynn Rosenberg, Joellen M Schildkraut, Holly R. Harris. Genital powder use and risk of epithelial ovarian cancer in the Ovarian Cancer in Women of African Ancestry Consortium [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-180.