Introduction: Aggressive angiomyxoma (AAM) is a rare, locally aggressive, benign tumor usually found in the female pelvis. Case Report: We present a 42-year-old Caucasian female undergoing removal of a non-enlarging, painless vulvar mass at time of hysteroscopic endometrial ablation for abnormal uterine bleeding. The patient had a past medical history notable for multiple malignant melanomas. Past surgical history included three low transverse cesarean sections, postpartum tubal ligation, and three wide excisions of melanomas. Family history was negative for dermatologic disease or cancers. The mass had been present for over two years; she desired removal for cosmetic purposes. At the time of surgery, the patient was asymptomatic and physical examination revealed a soft, mobile, approximately 2 cm, non-tender right labial mass. Previous ultrasound report described the mass as 2 × 2 cm and solid-appearing. During the surgery, a 5 × 2.6 × 1.4 cm irregular mass with soft, spongy contents was removed intact via incision followed by blunt and sharp dissection. Pathology of the specimen revealed AAM, with extension of tumor to the surgical margins. Histology and immunohistochemistry reports
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