The age-related changes in body chemical composition were measured in a normal black population ranging in age from 30 to 80 yr. The levels of total-body calcium, phosphorus, sodium, and chlorine were measured by in vivo neutron activation. In addition, the lean body mass (total-body potassium) was measured by whole-body counting of 40K. These data were compared with the same data obtained on a normal white population in a previous study. Although there were no significant differences in the height of the two groups, black men and women had significantly higher total-body calcium, phosphorus, sodium, chlorine, and potassium than the sex-and age-matched white population. The increased levels of total-body calcium and potassium when normalized for the weight and height of the subjects were reduced but still remained significantly higher than those of the white population. Clearly specific reference standards for skeletal and muscle mass as well as for sodium and chlorine need to be established for black populations.
The techniques of photon absorptiometry of the radius and total body neutron activation analysis were used for the determination of bone mineral content and total body calcium, respectively. The subjects consisted of 71 normal women who were 1-5 yr postmenopausal and 44 osteoporotic women who had crush fractures of the dorsal spine. Both bone mineral content and total body calcium were corrected for age and body size by using the ratio of observed values to those predicted from previously derived equations. Discrimant analysis involving both osteoporotic and normal postmenopausal women resulted in the successful assignment of 81% of the 115 subjects to their correct group. Statistical analyses of the distribution of the bone mass of the postmenopausal women yielded no evidence to support the hypothesis that a subgroup exists with bone mass levels markedly different from the remainder of the women.
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