The best anesthesiologic approach to severe AS patient has not been adequately studied in literature. Although the current guidelines have a cautious attitude in this regard, Combined Spinal-Epidural Anesthesia (CSEA) has proved to be a safe technique. Therefore, we would like to provide our experience with a severe AS and COVID-19 patient.

A 42‐year‐old male patient with Arnold‐Chiari malformation type 1,5 (ACM‐1,5) came to implant a hip prosthesis. He underwent a previous general anesthesia, with difficult airway management and complication in awakening. In this second surgery, an extradural approach was preferred to keep intracranial pressure and hemodynamics stable.

The “Severe Acute Respiratory Syndrome Coronavirus 2” (SARS-CoV-2) causes potentially fatal disease.The Covid-19 vaccine is the most effective weapon to reduce the virus spread. We describe a rare post-vaccine effect like Guillian Barré Syndrome. We reported a 66-years-old female patient with acute manifestations four weeks after vaccine administration.