The Matteson reaction
is ideally suited for flow chemistry since
it allows iterative homologation of boronate esters. The present study
provides accurate data on reaction times of the individual steps of
the Matteson reaction, which occurs in less than 10 s in total. The
protocol allows terpenes to be (per-)homologated in a controlled manner
to yield homo-, bishomo-, and trishomo-terpenols after oxidative workup.
The new terpene alcohols are validated with respect to their olfactoric
properties.
Inductive heating has developed into a powerful and rapid indirect heating technique used in various fields of chemistry, but also in medicine. Traditionally, inductive heating is used in industry, e.g., for heating large metallic objects including bending, bonding, and welding pipes. In addition, inductive heating has emerged as a partner for flow chemistry, both of which are enabling technologies for organic synthesis. This report reviews the combination of flow chemistry and inductive heating in industrial settings as well as academic research and demonstrates that the two technologies ideally complement each other.
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