The 3-0-D-glueuronide triacetate methyl esters of estrone, 170-estradiol, estriol, equilin, and equilenin and the 3-0-D-glucoside tetraacetate of estrone were obtained in yields of 46-71% by direct crystallization from a Koenigs-Knorr reaction using a glycosyl halide and the novel catalyst, cadmium carbonate. This represents an approximately tenfold improvement in yield over previously reported methods. Evidence was obtained which suggests that the actual catalyst in these reactions is the resulting cadmium halide. Among the identified byproducts were small amounts of the corresponding a anomers and the steroidal 3-acetates. A 4-C-glucuronosyl derivative of equilenin was also obtained in 14% yield. The products were deblocked by standard methods to

No abstract

No abstract

No abstract