whether grade of stenosis, or also treatment delay, or all three criteria (gender, delay and grade of stenosis) were considered. When 150 (17.7%) asymptomatic patients were added to the most precise calculation, the SPP of CEAs decreased from 201.4 to 181.5. Increasing proportion of asymptomatic patients up to 50% or 75% would have decreased the corresponding SPP down to 145.0 or 116.9 for our cohort. The SPP for symptomatic patients (including all subgroups) was 140.8, 159.9 and 179.1 with theoretical 6%, 3% and 0% complication rates, respectively. When the figures for asymptomatic patients on statin treatment at the time of randomization in ACST-1 were used, the SPP for our cohort was 169.5, but if the proportion of asymptomatic patients would have increased to 50% or 75% the SPP would have gone down to 111.2 or 66.7, respectively. Conclusion-From the same cohort of operated patients strokes prevented per 1000 operations in 5 years varied between 145.9 and 201.4 depending on which factors were taken into account. We recommend that grade of stenosis, gender and delay be all considered when the stroke preventing power of CEA services are reported. This may be particularly important when national and international comparisons are made from registered data. References 1. Rothwell PM, Eliasziw M, Gutnikov SA, Warlow CP, Barnett HJM. Sex-difference in effect of time from symptoms to surgery on benefit from carotid endarterectomy for TIA and non-disabling stroke. Stroke. 2004;35:2855e2861 2. Naylor AR. An update on the randomized controlled trials of interventions for symptomatic and asymptomatic carotid artery disease.
Therefore, tight perioperative blood pressure (BP) control is an essential component of stroke prevention after CEA. Despite the importance of in-hospital perioperative hemodynamics, little is known of BP changes in the first weeks after CEA. Self-measurement of BP at home could close this knowledge gap and might help targeting patients who are most at risk. It might also allow earlier recognition of deterioration and early intervention. In this pilot study, we asked patients who had undergone CEA to perform BP measurements twice daily at home during the first 30 days after discharge and observed BP remotely. The primary study aim was to assess feasibility and patient experiences with daily BP self-measurement. Secondary, to gain insight into postoperative BP trends. Methods: Thirty patients undergoing CEA at a tertiary referral center, were included in this study. Patients received an ambulatory BP monitor (OMRON HEM-9210T, Healthcare Co.Lt., Kyoto, Japan) that transmits BP values to a secured online dashboard via a telemonitoring application (Luscii Vitals, Luscii Healthtech BV, Amsterdam, the Netherlands) on iPad. Patients were trained to use the equipment and asked to record BP twice daily for 30 days after hospital discharge. For each patient, systolic BP restrictions were determined based on postoperative increase of cerebral blood flow measured by Transcranial Doppler (TCD). An alert was generated if BP exceeded this threshold with !15%. If four consecutive alerts were generated, patients were requested to visit the outpatient clinic. At the end of the study, patients were asked to complete a survey regarding their experiences and perceived feasibility of home BP monitoring following CEA. We also recorded patient adherence to the monitoring protocol, BP time series, and any interventions. Results: Patient age was 68(AE8) years (87% male). Ninety percent had symptomatic stenosis, and 90% underwent internal carotid CEA. Five patients(17%) were prolonged observed postoperatively in a high care unit, two(7%) had TCD-measured cerebral hyperperfusion, and six(20%) had a postoperative event (bleeding:2, TIA:2, myocardial infarction:1; one patient was readmitted for stress-induced hypertension). One patient visited his general practitioner for concerns regarding high BP values recorded at home. Patient adherence to home BP measurement was high; 24 patients provided !90% of the expected BP measurements. Regarding feasibility, 67% of patients experienced home BP monitoring as very positive, and 25% moderately positive. All patients except one would recommend home BP monitoring as part of standard care after CEA. In no patients four consecutive BP measurements exceeded the individual systolic BP threshold. Mean intra-individual variability of systolic and diastolic BP of all patients was 13.2mmHg and 7.4mmHg, respectively. No significant differences in variability of systolic BP measurements were found between patients with an event and those without an event. Conclusion: Postoperative home BP monitoring was well acc...
We pooled IPD from 11 of 32 eligible studies. From the remaining 21 studies, IPD could not be retrieved because of no response (n¼7), no IPD available (n¼12) and data from randomized controlled trial (n¼2) which resulted in a response rate of >75%. The total patient cohort consist of 703 patients of which 334 (48%) were treated with a carotid endarterectomy (CEA), 227 (32%) with carotid artery stenting (CAS) and 142 (20%) with BMT. Within 30 days, any stroke/death was reported in 8 patients (2.4%) in the CEA group, in 5 patients (2.2%) in the CAS group, and in 7 patients (4.9%) in the BMT group. These results were not significantly different between the three groups. Long-term outcome analysis will be available at the time of the ESVS conference. Conclusion-Based on these preliminary results, procedural outcome of CEA or CAS was within ranges of revascularization in low risk patients. However, outcomes of CEA or CAS were not significantly different from BMT treatment. Long-term outcome analysis will be available at the time of the ESVS conference.
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