The article presents the results of the study of vitamin D receptor (VDR) gene rs2228570 single nucleotide polymorphism (SNP) genotypes and individual alleles frequency among the Kazakh ethnic group representatives living in the Karaganda region. This SNP was determined by real-time polymerase chain reaction using TaqMan technology. The study relevance is due to the fact that genetic variations in rs2228570 affect the synthesis of the VDR protein and its activity as a transcription factor that regulates the expression of other genes. This mechanism determines the association of individual rs2228570 genotypes or alleles with susceptibility, course, and outcomes of various diseases. The polymorphism frequency may be depending on ethnicity. According to the study results, the most common genotypes of rs2228570 SNP among the Kazakhs were AG (32.8 %) and GG (25.2 %). The rarest are homozygotes TT (1.7 %) and CC (0.8 %). The frequency of all rs2228570 alleles was detected simultaneously in the present study for the first time. G became the predominant allele (51.3 %), less common was A (31.0 %), and the C and T alleles were the rarest (11.8 % and 5.9 %, respectively). The potential value of this SNP further study as a possible factor influencing the body’s susceptibility to various diseases, including COVID-19, is shown.

The article presents the results of genotyping of DNA samples obtained from study participants with the established status of coronavirus infection (COVID-19) using enzyme immunoassay for the single nucleotide polymorphism rs12329760 (C/T) of the TMPRSS2 gene. Genotyping was carried out by polymerase chain reaction (PCR) in real time using the technique “Amplification of the refractory mutation system” (ARMS). The distribution of frequencies of genotypes and alleles rs12329760 C>T of the TMPRSS2 gene in 80 people of the experimental and control groups was analyzed. The presence of the significance of the single nucleotide polymorphism rs12329760 of the TMPRSS2 gene in the homozygous state (CC) and heterozygous (CT) and the absence of the significance of the TT genotype was found. A statistically significant difference in the distribution of the T allele was found.