Management of recurrent haemoptysis poses a difficult clinical scenario. TISSEEL (Baxter Healthcare Corporation Deerfield, IL, USA) is a fibrin sealant often used in surgery to aid control of bleeding. However, when endoscopic TISSEEL is used independently, migration, dislodgement, or even expectoration of the fibrin clot is a common complication that may lead to recurrence of haemoptysis. Here we describe two patients with recurrent haemoptysis in the context of malignancy who underwent bronchoscopy, during which they were managed with application of topical TISSEEL to the bleeding area, followed by deployment of an intrabronchial valve, followed by a further application of TISSEEL over the valve. The combination of TISSEEL and intrabronchial valve appeared to control haemoptysis and was resistant to expectoration or migration in these two cases. Thus, this combination may provide a safe and effective therapeutic option for the control of bronchial bleeding secondary to malignancy.

Patients with granulomatosis with polyangiitis (GPA) may present with varied manifestations including pulmonary masses and nodules. We report the case of a 45‐year‐old man presenting with cough, haemoptysis and weight loss in the context of a 20 pack‐year past smoking history. Computed tomography (CT) of the chest and positron emission tomography/CT scan demonstrated two right upper lobe masses, bilateral lung nodules and mediastinal lymphadenopathy, with increased fluorodeoxyglucose avidity. Endobronchial and CT‐guided lung biopsy demonstrated granulomatous inflammation and elevated c‐ANCA/PR3 confirmed the diagnosis of GPA. The patient received induction therapy with methylprednisolone and rituximab with good clinical response. Our case highlights the importance of considering a wide range of differentials in patients with lung masses/nodules, including autoimmune pathologies.